Venous drainage ordinarily mirrors colonic arterial supply, with the inferior mesenteric vein draining into the splenic vein, and the superior mesenteric vein joining the splenic vein to configuration the portal vein that then enters the liver.
The proximal two-thirds of the transverse colon is perfused by the middle colic artery, a branch of superior mesenteric artery, while the later third is supplied by branches of intestinal parasite the inferior mesenteric artery. The "watershed" field between these two extraction supplies, which represents the embryologic division between the midgut and hindgut, is an area sensitive to ischemia.